HaplnScience

R&D

R&D

Pipeline
Project Basic Research Animal PoC Non-clinical Phase 1 Phase 2 Phase 3 BLA Remarks
HS-101 OA
Intra-Articular
HS-401 COPD
Inhalation
HS-201 Skin Aging
Intradermal
HS-301 Hair Loss
Intradermal
HS-101
Osteoarthritis
  • Cartilage Regeneration and Homeostasis Maintenance (Generation of cartilage > Degeneration of cartilage)
  • Improvement of Cartilage Composition (Generation of ECM components and hyaline cartilage)
  • Improvement of OA Symptoms (Relieving inflammation and pain)
  • Osteoarthritis (OA) is a degenerative chronic and inflammatory disease of joint cartilage damage, inflammation, and pain caused by age-related degeneration and/or repetitive trauma.
  • More than 300 million patients worldwide suffer from osteoarthritis due to the aging population and the increase of obesity.
  • Current treatment is limited to symptomatic improvement from inflammation and pain and there is no fundamental therapy for regeneration and recovery of damaged/degenerated cartilage.
Mechanism of Action
Expected Efficacy
Activation of anabolic signaling in cartilage

Selective activation of Smad2/3 signaling pathway

Symptom relief and regenerative effect

Efficacy in OA symptom relief and cartilage recovery

Fundamental treatment

Under development as a promising DMOAD (Disease-Modifying OA Drugs) candidate

HS-401
Chronic Obstructive Pulmonary Disease
  • Suppression of inflammation and degeneration caused by smoking and fine dust, etc.
  • Regeneration and recovery of Alveoli and bronchial tissue (Increase and activation of the receptors involved in tissue regeneration/recovery)
  • Normalization of lung function (Promoting and normalizing the synthesis of damaged/reduced elastin fibers, etc.)
  • Chronic Obstructive Pulmonary Disease (COPD) is a respiratory disease that causes obstructed airflow, accompanying pulmonary tissue damage and abnormal inflammatory response. Aging and smoking are the most common causes of COPD.
  • It leads to multiple complications such as emphysema, chronic bronchitis, asthma, and pulmonary hypertension
  • As current COPD treatments only focus on symptomatic relief such as reducing inflammation and bronchial dilation, there is no fundamental treatment that can regenerate and restore damaged pulmonary tissue.
Mechanism of Action
Expected Efficacy
Restoration of Alveoli and Bronchial Tissue

Induce the restoration of regenerative capacity by the synthesis of normal elastin fibers in alveoli and bronchial tissues and by the promotion of self-assembly

Fundamental treatment

Under development as a promising fundamental therapy by inhibiting chronic inflammation and airway obstruction, as well as normalizing lung function through tissue regeneration

HS-201
Skin Aging
  • Improvement of skin wrinkles caused by gradual loss of skin extracellular matrix due to aging and exposure to sunlight
  • Dual effect of promoting synthesis and inhibiting degradation of hyaluronic acid and collagen, based on cell biological mechanisms of aging
  • Skin rejuvenation effect by inducing ECM restoration and strengthening through normalization of aging and damaged skin cells
  • Strong efficacy in inhibiting chronic inflammation and reversing aging-associated degeneration through amplification of the communication and crosstalk between ECM and cell.
  • As skin aging and degeneration progresses, the content of collagen and hyaluronic acid, which are major components of the extracellular matrix, is decreased, and the need for rejuvenation of the skin tissues that lost elasticity and wrinkled is increased.
  • With the aging population and increasing interest in improving the quality of life, the global medical/esthetic market continues to grow at a rate of over 10% and is expected to reach $15.9 billion in 2025 1).
  • Products currently used in facial aesthetic treatments still have concerns about downtime and side effects due to the procedure, and the need for innovative treatments with safer and long-lasting natural improvement to replace them is increasing.
Reference 1. Markets and Markets
Mechanism of Action
Expected Efficacy
Normalization of Aging Skin Cells/Tissues

Normalizing damaged and reduced skin cells/tissues due to aging by strengthening the extracellular matrix through the cell biological aging mechanism

Improvement and Treatment Efficacy of Skin Aging (Wrinkles etc.)

Improvement and treatment of aging skin such as wrinkles expected by strengthening the extracellular matrix and normalizing senescent cells

Fundamental Treatment for Skin Aging

Regeneration and restoring effect based on the biological mechanism on aging skin that lost elasticity and wrinkled due to natural aging and exposure to light

HS-301
Hair Loss
  • Promotion of proliferating hair growth cells and growth effect utilizing HAPLN1, an endogenous protein specifically expressed in hair growth phase
  • Promoting TGF-beta signaling-dependent proliferation and growth-inducing effects of Human Hair Germinal Matrix Cells (HHGMCs) which are directly responsible for hair growth
  • Beta-catenin-dependent signaling activation which plays a central role in creating the hair follicle environment
  • A complex mechanism and strong hair growth effect through amplification of the ECM-to-cell and cell-to-cell crosstalk
  • Hair loss (Alopecia) is a disease caused by aging, stress, and environmental factors, and the number of people suffering from hair loss worldwide is estimated to be over 300 million1).
  • The currently available treatments are mainly for male hair loss, and there are still many needs for improvement in terms of efficacy and persistence as well as multiple side effects.
  • A drug applicable to various types of hair loss, and having good efficacy on the basis of biological aging mechanisms with not or very few side effects is on the market need.
Reference 1 . Research Nester
Mechanism of Action
Expected Efficacy
Restoring Degenerative Hair Follicle

Improvement in hair loss of various causes by restoring degenerative/damaged extracellular matrix in hair follicles

Normalizing HHGMCs

Restoring the signaling pathways in HHGMCs with HAPLN1 that is highly expressed in the hair growth phases

Applicable to Hair Loss of Various Causes

Developing as a hair loss treatment applicable to hair loss of various causes such as aging, stress, and hormonal abnormalities